Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review (CIR) flags 128 ingredients — 38 at the highest level.
2-Amino-4-Hydroxyethylaminoanisole and 2-Amino-4-Hydroxyethylaminoanisole Sulf…Unsafe / restricted→4-Chloro-2-AminophenolUnsafe / restricted→Acetamide MEAUnsafe / restricted→Capsicum Annum Extract, Capsicum Annuum Fruit Extract, Capsicum Annuum Resin…Unsafe / restricted→Cocamide DEAUnsafe / restricted→Cocamide DEA, Lauramide DEA, Linoleamide DEA, and Oleamide DEAUnsafe / restricted→Cocamide MEAUnsafe / restricted→Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine…Unsafe / restricted→DiethanolamidesUnsafe / restricted→Diisopropanolamine, Triisopropanolamine, Isopropanolamine…Unsafe / restricted→EthanolamidesUnsafe / restricted→Ethanolamine and Ethanolamine SaltsUnsafe / restricted→Ethoxyethanol and Ethoxyethanol AcetateUnsafe / restricted→Fatty Acyl Sarcosines and Their SaltsUnsafe / restricted→Final Report Isostearamide DEA & MEA, Myristamide DEA & MEA…Unsafe / restricted→FormaldehydeUnsafe / restricted→Formaldehyde and Methylene GlycolUnsafe / restricted→HydroquinoneUnsafe / restricted→Hydroquinone and Pyrocatechol (Pyrocatechol has been Amended. IJT 16(S1) 11-58…Unsafe / restricted→Hydroxyethyl-3,4-Methylenedioxyaniline HClUnsafe / restricted→p-PhenylenediamineUnsafe / restricted→p-Phenylenediamine, p-Phenylenediamine HCl and p-Phenlyenediamine SulfateUnsafe / restricted→p-Phenylenediamine, p-Phenylenediamine HCl and p-Phenylenediamine SulfateUnsafe / restricted→PCA (2-pyrrolidone-5-carboxylic acid) and its SaltsUnsafe / restricted→PCA and Sodium PCAUnsafe / restricted→PEG Propylene Glycol DerivativesUnsafe / restricted→PEG-20 Sorbitan Cocoate; PEG-40 Sorbitan Diisostearate; PEG-2, -5…Unsafe / restricted→PEG-25 Propylene Glycol Stearate, PEG-75 Propylene Glycol…Unsafe / restricted→Polyethylene Glycols (PEGs) -6, -8, -32, -75, -150, -14M, -20MUnsafe / restricted→PolysorbatesUnsafe / restricted→Quaternium-26Unsafe / restricted→Sodium Borate and Boric AcidUnsafe / restricted→TEA StearateUnsafe / restricted→TEA-Lauryl SulfateUnsafe / restricted→The Cosmetic Ingredient Review Program - Expert Safety Assessments of Cosmetic…Unsafe / restricted→Triethanolamine and Triethanolamine-Containing IngredientsUnsafe / restricted→Triethylene Glycol and PEG-4Unsafe / restricted→Triethylene Glycol and Polyethylene glycols (PEGs)-4, -6, -7, -8, -9, -10…Unsafe / restricted→2-Nitro-p-PhenylenediamineInsufficient data→2-Nitro-p-Phenylenediamine and 4-Nitro-o-PhenylenediamineInsufficient data→6-Amino-m-CresolInsufficient data→6-Amino-o-CresolInsufficient data→Acetyl Hexapeptide-8 AmideInsufficient data→Alkane DiolsInsufficient data→Aluminum Silicate, Calcium Silicate, Magnesium Aluminum Silicate…Insufficient data→Ammonium, Potassium, and Sodium PersulfateInsufficient data→Apple-Derived IngredientsInsufficient data→Avena sativa-Derived IngredientsInsufficient data→AzuleneInsufficient data→Basic Blue 7Insufficient data→Benzyl Alcohol, Benzoic Acid and its Salts, and Benzyl BenzoateInsufficient data→Benzyl Alcohol, Benzoic Acid, and Sodium BenzoateInsufficient data→Benzyl Alcohol, Benzoic Acid, Sodium BenzoateInsufficient data→BenzylparabenInsufficient data→Brown Algae-Derived IngredientsInsufficient data→ButoxyethanolInsufficient data→Camellia sinensis-Derived IngredientsInsufficient data→Capryloyl Salicylic AcidInsufficient data→Carica papaya (Papaya)-Derived IngredientsInsufficient data→Citrus Plant- and Seed-Derived IngredientsInsufficient data→Cocos nucifera (Coconut)-Derived IngredientsInsufficient data→Cross-Linked Alkyl AcrylatesInsufficient data→Dichlorophene and ChloropheneInsufficient data→Dimethicones, Methicone and Substituted-Methicone PolymersInsufficient data→Disperse Blue 7Insufficient data→Final Report: Amended Safety Assessment Naturally-Sourced ClaysInsufficient data→Ginkgo biloba-Derived IngredientsInsufficient data→Glucose GlutamateInsufficient data→GlycolactonesInsufficient data→GlyoxalInsufficient data→Glyoxal (Amended final report 6/97)Insufficient data→Helianthus annuus(Sunflower)-Derived IngredientsInsufficient data→Isobutylparaben and IsopropylparabenInsufficient data→Linear Phenyl-Substituted MethiconesInsufficient data→Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract…Insufficient data→Mentha Piperita (Peppermint)-Derived IngredientsInsufficient data→Methylparaben, Ethylparaben, Propylparaben, and ButylparabenInsufficient data→Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben…Insufficient data→Nelumbo nucifera-Derived IngredientsInsufficient data→o-Cymen-5-olInsufficient data→Olea europaea (Olive)-Derived IngredientsInsufficient data→Oxyquinoline and Oxyquinoline SulfateInsufficient data→p-Chloro-m-CresolInsufficient data→Paeonia suffruticosa-Derived IngredientsInsufficient data→ParabensInsufficient data→PersulfatesInsufficient data→Phenyl TrimethiconeInsufficient data→Piper Methysticum Leaf/Root/Stem Extract and Piper Methysticum Root ExtractInsufficient data→Plant-Derived Proteins and PeptidesInsufficient data→Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride)Insufficient data→Polyfluorinated PolymersInsufficient data→Polyol PhosphatesInsufficient data→Polyoxyalkylene Siloxane Copolymers…Insufficient data→Polysaccharide GumsInsufficient data→Polyvinyl AcetateInsufficient data→Polyvinyl Acetate (Amended report JACT 15(2) 166-176 1996)Insufficient data→Polyvinylpyrrolidone (PVP)Insufficient data→Polyvinylpyrrolidone/Vinyl Acetate CopolymerInsufficient data→Potassium Silicate, Sodium Metasilicate, and Sodium SilicateInsufficient data→Punica granatum(Pomegranate)-Derived IngredientsInsufficient data→Red Algae-Derived IngredientsInsufficient data→Rereview not opened - use not supported: Glyceryl Collagenate…Insufficient data→Rereview not opened: Glyceryl Isostearates and Glyceryl Stearate/AcetateInsufficient data→Rosa centifolia-Derived IngredientsInsufficient data→Safety of Oxyquinoline and Oxyquinoline SulfateInsufficient data→Salvia officinalis (Sage)-Derived IngredientsInsufficient data→Scutellaria baicalensis-Derived IngredientsInsufficient data→Silica, Alumina Magnesium Metasilicate, Aluminum Calcium Sodium Silicate…Insufficient data→SilicatesInsufficient data→Silk Protein IngredientsInsufficient data→Sodium Naphthalenesulfonate and Sodium PolynaphthalenesulfonateInsufficient data→Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, Mixed Cresols…Insufficient data→Sodium Polynaphthalenesulfonate and Sodium NaphthalenesulfonateInsufficient data→Soy-Derived IngredientsInsufficient data→Stearoxy Dimethicone, Dimethicone, Methicone, Amino Bispropyl Dimethicone…Insufficient data→Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic AcidInsufficient data→Titanium ComplexesInsufficient data→Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate and Toluene-3,5-DiamineInsufficient data→Toluene-2,5-Diamine, Toluene-2,5-Diamine Sulfate, and Toluene-3,4-DiamineInsufficient data→Tragacanth GumInsufficient data→Trimellitic Anhydride CopolymersInsufficient data→VanillaInsufficient data→Vinylpyrrolidone PolymersInsufficient data→Wheat Flour and Wheat StarchInsufficient data→Wheat Germ Glycerides and Wheat GlutenInsufficient data→Wheat-Derived IngredientsInsufficient data→Yeast-Derived IngredientsInsufficient data→Zingiber officinale (Ginger)-Derived IngredientsInsufficient data→
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CIR is an independent expert panel that reviews published scientific literature to assess the safety of cosmetic ingredients. The panel issues findings of Safe, Safe with Qualifications, Unsafe, or Insufficient Data. Reviews follow a structured process: priority list, scientific literature review, tentative report, public comment period, and final report. Each ingredient assessment typically spans 1-2 years.
Jurisdiction
US
Founded
1976