Keratin 6A promotes skin inflamma…on in keratinocytes.
🔬 Peer-reviewed
Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes.
Mengting Chen, Yaling Wang, Mei Wang, San Xu, Zixin Tan, Yisheng Cai + 4 more
Journal of biomedical science · 2025
Findings
Keratin 6A (KRT6A), a protein your skin naturally makes, actually makes inflammation worse in conditions like rosacea and psoriasis. When researchers reduced KRT6A in inflamed skin, inflammation improved; when they increased it, inflammation got worse. The protein works by triggering a specific inflammatory pathway (JAK1-STAT3) that ramps up irritation.
Design
Review
Evidence
Moderate
Journal
Journal of biomedical science
Ingredients studied