The Key Role of GM1 Ganglioside i…Parkinson's Disease.
🔬 Peer-reviewed
The Key Role of GM1 Ganglioside in Parkinson's Disease.
Suman Chowdhury, Robert Ledeen
Biomolecules · 2022
Findings
Researchers found that people with Parkinson's disease have lower levels of GM1 ganglioside (a fatty molecule) in their brain, nervous system, and skin. This deficiency showed up not just in brain tissue but also in skin cells and immune cells, suggesting it's a widespread problem in PD—not just a brain issue. Mouse studies supported this finding and suggested that replacing GM1 could potentially help treat the disease.
Design
Review
Evidence
Moderate
Journal
Biomolecules