Oxidized limonene and oxidized li…fragrance terpenes.
🔬 Peer-reviewed
Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes.
Johanna Bråred Christensson, Ann-Therese Karlberg, Klaus E Andersen, Magnus Bruze, Jeanne D Johansen, Begoña Garcia-Bravo + 4 more
Contact dermatitis · 2016
Findings
When fragrance ingredients linalool and limonene oxidize (break down over time), they can trigger allergic contact dermatitis. In patch tests of nearly 3,000 dermatitis patients across 6 countries, about 6% reacted to oxidized linalool and 5% to oxidized limonene—but only 25% of allergic patients reacted to both, meaning most people were sensitized to one or the other, not both.
Design
Cohort
Sample
n=281
Evidence
Moderate
Journal
Contact dermatitis
Ingredients studied