Tumor-resident Lactobacillus iner…metabolic rewiring.
🔬 Peer-reviewed
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring.
Lauren E Colbert, Molly B El Alam, Rui Wang, Tatiana Karpinets, David Lo, Erica J Lynn + 39 more
Cancer cell · 2023
Findings
Researchers found that Lactobacillus iners, a bacterium found in tumors, made cervical cancer cells resistant to chemotherapy and radiation treatment, and was linked to worse patient survival. The same type of lactic acid-producing bacteria showed similar concerning patterns across colorectal, lung, head and neck, and skin cancers. Bottom line: this bacterium fundamentally changes how cancer cells metabolize energy, making treatments less effective.
Design
Cohort
Evidence
Moderate
Journal
Cancer cell
Ingredients studied