Efficacy and Safety of the Combin…Diabetic Neuropathy.

🔬 Peer-reviewed

Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy.

Triantafyllos Didangelos, Eleni Karlafti, Evangelia Kotzakioulafi, Parthena Giannoulaki, Zisis Kontoninas, Anastasia Kontana + 4 more

Nutrients · 2024

Findings

A 6-month study of 73 people with diabetic nerve damage found that a supplement combo (containing SOD, alpha lipoic acid, B vitamins, and minerals) reduced pain scores by about 33% and improved nerve function markers like vibration sensation and nerve conduction speed. The placebo group saw no improvement in pain and actually experienced worsening nerve damage, making the difference between groups statistically significant.

Design

Randomized Controlled Trial

Evidence

Strong

Journal

Nutrients