Butylated Hydroxytoluene (BHT) Pr…and In Vivo Studies.

🔬 Peer-reviewed

Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies.

Parisa Faraji, Astrid Borchert, Shahin Ahmadian, Hartmut Kuhn

Antioxidants (Basel, Switzerland) · 2024

Findings

BHT stopped nerve cell death in lab tests by acting as an antioxidant—it prevented damage from harmful molecules and protected a specific enzyme (glutathione peroxidase 4) that cells need to survive. In rats with Alzheimer's-like conditions, BHT also reduced the expression of genes linked to this type of cell death, suggesting it might have protective effects in the brain.

Design

In-vitro

Evidence

Preliminary

Journal

Antioxidants (Basel, Switzerland)