Safety Assessment of PCA (2-Pyrro…s Used in Cosmetics.

🛡️ Safety-assessed

Safety Assessment of PCA (2-Pyrrolidone-5-Carboxylic Acid) and Its Salts as Used in Cosmetics.

Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler + 6 more

International journal of toxicology · 2019

Findings

Sodium PCA and related salt forms (calcium, magnesium, potassium) are safe for use in cosmetics at current concentration levels. The main catch: they shouldn't be used in products where N-nitroso compounds could form, which is a specific chemical concern rather than a general safety issue.

Design

Review

Evidence

Moderate

Journal

International journal of toxicology