Efficacy and Safety of a Fixed-Do…le-Combination Drug.

🔬 Peer-reviewed

Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug.

Linda Stein Gold, Hilary Baldwin, Leon H Kircik, Jonathan S Weiss, David M Pariser, Valerie Callender + 8 more

American journal of clinical dermatology · 2022

Findings

In a 12-week study of 741 people with moderate-to-severe acne, the triple-combo gel (clindamycin + benzoyl peroxide + adapalene) cleared skin in 52.5% of users versus 8.1% with placebo. It reduced inflammatory spots by about 30 and non-inflammatory ones by about 35, outperforming two-ingredient versions. Side effects were mostly mild to moderate.

Design

Randomized Controlled Trial

Sample

n=741

Evidence

Strong

Journal

American journal of clinical dermatology