Senolytics decrease senescent cel…etic kidney disease.

🔬 Peer-reviewed

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

LaTonya J Hickson, Larissa G P Langhi Prata, Shane A Bobart, Tamara K Evans, Nino Giorgadze, Shahrukh K Hashmi + 27 more

EBioMedicine · 2019

Findings

In a small 9-person study, a 3-day treatment combining Dasatinib and Quercetin reduced senescent cells (aging cells that trigger inflammation) in skin and fat tissue within 11 days. The treatment also lowered inflammatory markers in the blood, including IL-6 and MMPs, which are linked to skin aging and degradation.

Design

Review

Evidence

Moderate

Journal

EBioMedicine