Topically applied GHK as an anti-…ems and prospective.
🔬 Peer-reviewed
Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective.
Seyedeh Maryam Mortazavi, Seyyed Ali Mohammadi Vadoud, Hamid Reza Moghimi
BioImpacts : BI · 2025
Findings
Lab studies show GHK peptide can boost collagen production and reduce wrinkles, but here's the catch: most versions used in actual products haven't been tested on real human skin. The researchers found that GHK struggles to penetrate skin deeply enough to work—it's too water-soluble and breaks down easily—which means the anti-wrinkle claims may not translate from the lab to your face.
Design
Review
Evidence
Moderate
Journal
BioImpacts : BI