Final report on the safety assess…30-45 alkyl methicon

Dimethicone and related silicone polymers showed minimal to no absorption through skin and weren't toxic in animal studies at concentrations up to 10-79%. The ingredient caused minimal skin and eye irritation in rabbits, didn't trigger allergic reactions in guinea pigs or humans (including a 83-person patch test), and showed no reproductive or developmental harm—though one study noted decreased body weight in treated male rats.