Botanical Briefs: Neem Oil (Azadirachta indica).

Neem oil has legitimate medicinal properties and is used to treat various skin conditions. However, the study documents a rare but real side effect: a 77-year-old man developed a permanent loss of skin pigmentation (hypopigmentation) after 6 months of repeated neem oil application. This suggests that while neem can be beneficial, repeated topical use needs caution.