2-Mercaptonicotinoyl glycine, a n…elanocyte integrity.

🔬 Peer-reviewed

2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity.

Peggy Sextius, Emilie Warrick, Amélie Prévot-Guéguiniat, Guillaume Lereaux, Florence Boirre, Ludwig Baux + 8 more

Pigment cell & melanoma research · 2024

Findings

Researchers discovered 2-mercaptonicotinoyl glycine (2-MNG), a new ingredient that reduces dark spots and uneven skin tone by blocking melanin production before it forms—without damaging melanocytes (the cells that make melanin). Unlike most existing brightening actives, 2-MNG works through a completely different mechanism and showed effectiveness when applied topically to human skin.

Design

Review

Evidence

Moderate

Journal

Pigment cell & melanoma research

Ingredients studied

Glycine →