Anti-inflammatory effects of phyt…and MAPK mechanism.

🔬 Peer-reviewed

Anti-inflammatory effects of phytosphingosine-regulated cytokines and NF-kB and MAPK mechanism.

Mikyung Sung, Sojung Lim, Seungwon Park, Yongjin Choi, Sangchul Kim

Cellular and molecular biology (Noisy-le-Grand, France) · 2024

Findings

Phytosphingosine reduced multiple inflammatory markers in skin cells, including nitric oxide, prostaglandin E2, and several pro-inflammatory cytokines (IL-6, IL-8, IL-10). It worked by blocking two major inflammatory signaling pathways in cells (NF-κB and MAPK), suggesting it could help calm skin conditions triggered by immune stress.

Design

Review

Evidence

Moderate

Journal

Cellular and molecular biology (Noisy-le-Grand, France)

Ingredients studied

Phytosphingosine →