Ergothioneine regulates the parac…hair follicle aging.

🔬 Peer-reviewed

Ergothioneine regulates the paracrine of dermal papilla cells through SIRT1/Nrf2 pathway to antagonize oxidative stress and natural hair follicle aging.

Hailin Wang, Yueying Wang, Xin Li, Jiayang Ma, Zhiqi Hu, Qian Qu + 1 more

Free radical biology & medicine · 2025

Findings

Ergothioneine, an antioxidant found in mushrooms, reduced hair graying and loss in aged mice and mice with chemically-induced gray hair by protecting hair follicle cells from oxidative damage. It boosted production of pigmentation-promoting factors and increased melanin content in skin cells. The compound worked by activating specific cellular pathways (SIRT1/Nrf2) that fight oxidative stress.

Design

Review

Evidence

Moderate

Journal

Free radical biology & medicine