Niacinamide — Mechanisms of Actio…l Use in Dermatology

Niacinamide strengthens the skin barrier, reduces inflammation, regulates sebum production, and inhibits melanin transfer via multiple molecular pathways

This review detailed the molecular mechanisms behind niacinamide's dermatological benefits. Niacinamide (vitamin B3) increases ceramide and fatty acid synthesis in the stratum corneum, strengthening the skin barrier. It inhibits NF-κB signaling to reduce inflammation, suppresses melanosome transfer to keratinocytes (reducing hyperpigmentation), and regulates sebum production. The review established niacinamide as one of the most versatile and well-tolerated active ingredients in topical skincare, supporting its widespread adoption in clean beauty.

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