Madecassic acid, the contributor…γ/AMPK/ACC1 pathway.

🔬 Peer-reviewed

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway.

Xiaotian Xu, Yuhui Wang, Zhifeng Wei, Wenhui Wei, Peng Zhao, Bei Tong + 2 more

Cell death & disease · 2017

Findings

Madecassic acid (a compound from Centella asiatica) reduced inflammatory markers in mice with colitis by shifting immune cells away from inflammation-promoting Th17 cells toward calming Treg cells. When given orally, it decreased inflammatory proteins like IL-17A and IL-17F while increasing anti-inflammatory IL-10. This worked through a specific cellular pathway (PPARγ/AMPK), but the study was done in mice—we don't have human skin or gut data yet.

Design

Review

Evidence

Moderate

Journal

Cell death & disease