Retinoids: Active Molecules Influ…tological Treatments

🔬 Peer-reviewed

Retinoids: Active Molecules Influencing Skin Structure Formation in Cosmetic and Dermatological Treatments

Zasada M, Budzisz E

Advances in Dermatology and Allergology · 2019

Findings

Newer retinoid derivatives (retinaldehyde, hydroxypinacolone retinoate) offer efficacy closer to tretinoin with reduced irritation

Design

Review

Evidence

Moderate

Journal

Advances in Dermatology and Allergology

Methodology

This review examined the spectrum of retinoids used in both cosmetic and dermatological applications, comparing their mechanisms, efficacy, and tolerability. The authors described the retinoid conversion pathway (retinyl esters → retinol → retinaldehyde → retinoic acid) and evaluated newer derivatives including hydroxypinacolone retinoate (HPR) and retinaldehyde that offer efficacy closer to prescription tretinoin with less irritation. The review is useful for understanding the hierarchy of retinoid ingredients found in clean beauty products.

Funded By

Medical University of Lodz

🧂Conflict of interest.