Insulin-like growth factor-bindin…ce to heart failure.

🔬 Peer-reviewed

Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure.

Liyong Zhang, David Smyth, Mohammad Al-Khalaf, Alice Blet, Qiujiang Du, Jordan Bernick + 13 more

Nature cardiovascular research · 2022

Findings

Researchers found that a protein called IGFBP7 is significantly elevated in heart failure patients and contributes to aging of heart cells. When they blocked IGFBP7 in mice with heart disease, cardiac function improved, inflammation decreased, and cells showed better ability to repair DNA damage and neutralize harmful free radicals.

Design

Review

Evidence

Moderate

Journal

Nature cardiovascular research