Caffeic acid-vanadium nanozymes t…apoptotic proteins.

🔬 Peer-reviewed

Caffeic acid-vanadium nanozymes treat skin flap ischemia-reperfusion injury through macrophage reprogramming and the upregulation of X-linked inhibitors of apoptotic proteins.

Xinyu Zhao, Jie Shan, Hanying Qian, Xu Jin, Yiwei Sun, Jianghao Xing + 3 more

Acta pharmaceutica Sinica. B · 2025

Findings

Researchers created nanoparticles combining caffeic acid (a plant compound) with vanadium that reduced oxidative stress and inflammation in lab and animal models of skin flap transplants. The particles reduced harmful free radicals, lowered inflammatory markers (CCL4 and CXCL2), and improved skin flap survival rates in animal tests. This is early-stage research—it hasn't been tested on human skin yet.

Design

Review

Evidence

Moderate

Journal

Acta pharmaceutica Sinica. B