The key role of hyaluronic acid m…nment reprogramming.
🔬 Peer-reviewed
The key role of hyaluronic acid molecular weight in HIF-1α pathway-mediated hypoxic microenvironment reprogramming.
Jing Liu, Meishan Piao, Yunxing Li, Cheng Yang, Bingtian Zhao
International journal of biological macromolecules · 2025
Findings
Researchers tested three different sizes of hyaluronic acid and found that medium-sized HA (around 30.8 kDa) worked best at reducing inflammation and oxidative stress in oxygen-deprived skin conditions. In animal tests, this specific size promoted new blood vessel growth and skin cell regeneration in wounded tissue—suggesting HA's benefits depend heavily on its molecular weight, not just its presence.
Design
Review
Sample
n=30
Evidence
Moderate
Journal
International journal of biological macromolecules
Ingredients studied