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Hyaluronic Acid
AKA “3S, 4R, 5R, 6R)-3-{[(2S, 3R, 5S, 6R)-4-{[(2R, 4S”
Acid
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Ingredient Facts
Hyaluronic acid
AKA: 3S, 4R, 5R, 6R)-3-{[(2S, 3R, 5S, 6R)-4-{[(2R, 4S
Acid · Humectant In Cosmetic Products · EWG: 1
Synthetic
Humectant
Hyaluronic Acid
Acid
Clean
Restricted:EWG VERIFIED products cannot contain this ingredient without adequate substantiation.
CAS #
9004-61-9
Form
Liquid
State
Solid
See origin →
Functions
Humectant In Cosmetic Products
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
Traditional Use
Discovered in 1934 in bovine eye tissues; originally identified as a component of the extracellular matrix. Recognized in skincare from the 1990s onward for its exceptional water-binding capacity, inspired by the body's natural hyaluronic acid found in skin, joints, and connective tissue.
Skin Types
●all-skin-types, gentle
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Potential Sensitizer
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Age-Defying Fundamentals
Odacité
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Anti-aging Dream Duo • SPF 50 + Retinol
Odacité
 →
Anti Aging Eye & Sun Defense Duo
Odacité
 →
Bioactive Renew Supreme Cream • Edelweiss Extrême® • Peptides + Carnosine
Odacité
 →
Black Tulip Eye Treatment
Bloom Effects
 →
Bonne Nuit™ Night Cream
Pai Skincare
 →
Clean-ical Formulations AM + PM Serum Duo
Odacité
 →
Clearing Mask
Indie Lee
 →
CoQ-10 Toner Home & Travel Duo
Indie Lee
 →
Day & Night Eye Care Duo
Odacité
 →
Doctor's Scrub Advanced
Goldfaden MD
 →
Derm-Restore Super Serum • Edelweiss Extrême® • Peptides + Carnosine
Odacité
 →
Edelweiss Extrême® • Repair + Restore Set
Odacité
 →
Edelweiss Extrême® Skin Barrier Set
Odacité
 →
Gentle Body Wash - Vanilla
Kinship
 →
Hyaluronic Acid 0.3% Hydrating Booster
Pai Skincare
 →
I-Waken Eye Serum
Indie Lee
 →
Hotliner
Kosas
 →
Light Treatment
Goldfaden MD
 →
Love + Rose Hydrating Serum
One Love Organics
 →
Moisturizing Body Cream - Unscented
Kinship
 →
Moisturizing Body Cream - Vanilla
Kinship
 →
Morning + Night Serum Set
Kinship
 →
Needle-less
Goldfaden MD
 →
Winter Renewal Ritual
Odacité
 →
Plant Profusion Energetic Eye Cream
Goldfaden MD
 →
Plant Profusion Neck Cream
Goldfaden MD
 →
Plant Profusion Night Cream
Goldfaden MD
 →
Radiance Boosting Starter Set
Goldfaden MD
 →
Radiance Renewal Eye Duo
Goldfaden MD
 →
Radical Difference
Goldfaden MD
 →
Ready, Set, Smooth
Goldfaden MD
 →
Refreshing Water Cream
COOLA
 →
Refreshing Water Hydration Stick
COOLA
 →
Refreshing Water Plumping Gel Serum
COOLA
 →
Restorative Body Serum - Unscented
Kinship
 →
Restorative Body Serum - Vanilla
Kinship
 →
Resurrection Girl™ Mask
Pai Skincare
 →
Rewakening™ Rosewater Mist
COOLA
 →
Radiance Lock Setting Mist
RMS Beauty
 →
Bestsellers Bundle
Saie
 →
Complexion Boost
Saie
 →
Concealer Brush Duo
Saie
 →
Glossybounce™
Saie
 →
Glossybounce™ Duo
Saie
 →
Glossybounce™ Duo
Saie
 →
Glow Sculpt™
Saie
 →
Glowy Super Skin Tint Foundation
Saie
 →
Lip Combo
Saie
 →
Skin Glow Duo
Saie
 →
Hyaluronic Acid: Redefining Its Role.
Abatangelo G, Vindigni V, Avruscio G, Pandis L, Brun P
Cells, 2020
→
Final report of the safety assessment of hyaluronic acid,...
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, James G Marks, Ronald C Shank + 3 more
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid,...
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, James G Marks, Ronald C Shank + 3 more
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid,...
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Curtis D Klaassen, James G Marks, Ronald C Shank + 3 more
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate.
Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
→
Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence.
Bravo B, Correia P, Gonçalves Junior JE, Sant'Anna B, Kerob D
Dermatologic therapy, 2022
→
Benefits of topical hyaluronic acid for skin quality and ...
Bruna Bravo, Priscila Correia, José Euzébio Gonçalves Junior, Beatriz Sant'Anna, Delphine Kerob
Dermatologic therapy, 2022
→
Final Report on the Safety Assessment of Hyaluronic Acid, Sodium Hyaluronate, and Potassium Hyaluronate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Hyaluronic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrolyzed Hyaluronic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers.
De Boulle K, Glogau R, Kono T, Nathan M, Tezel A et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013
→
Hyaluronic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydrolyzed Hyaluronic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hyaluronic acid-lipid binding.
Ewurum A, Alur AA, Glenn M, Schnepf A, Borchman D
BMC chemistry, 2021
→
Hyaluronic acid-lipid binding.
Ewurum A, Alur AA, Glenn M, Schnepf A, Borchman D
BMC chemistry, 2021
→
Hyaluronic acid-lipid binding.
Ewurum A, Alur AA, Glenn M, Schnepf A, Borchman D
BMC chemistry, 2021
→
Hyaluronic acid-lipid binding.
Ewurum A, Alur AA, Glenn M, Schnepf A, Borchman D
BMC chemistry, 2021
→
Hyaluronic acid-lipid binding.
Ewurum A, Alur AA, Glenn M, Schnepf A, Borchman D
BMC chemistry, 2021
→
Hyaluronic Acid in the Third Millennium.
Fallacara A, Baldini E, Manfredini S, Vertuani S
Polymers, 2018
→
Effect of a New Hyaluronic Acid Hydrogel Dermal Filler Cr...
Yanping Guo, Wuhan Wei, Haoyu Wang, Qiang Li, Changzheng Wei, Jingyu Zhang + 1 more
Aesthetic surgery journal, 2023
→
Hyaluronic Acid-like Skin Plumping and Radiance Benefits of a Porphyridium Sulfated Exopolysaccharide- and Natural PDRN-Rich Extract.
Havas F, Krispin S, Cohen M, Attia-Vigneau J
Marine drugs, 2026
→
The key role of hyaluronic acid molecular weight in HIF-1...
Jing Liu, Meishan Piao, Yunxing Li, Cheng Yang, Bingtian Zhao
International journal of biological macromolecules, 2025
→
The key role of hyaluronic acid molecular weight in HIF-1...
Jing Liu, Meishan Piao, Yunxing Li, Cheng Yang, Bingtian Zhao
International journal of biological macromolecules, 2025
→
Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable M
Miura S, Yamagishi R, Miyazaki R, Yasuda K, Kawano Y et al.
Gels (Basel, Switzerland), 2022
→
Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention.
Ni C, Zhang Z, Wang Y, Zhang Z, Guo X et al.
Journal of controlled release : official journal of the Controlled Release Society, 2023
→
Hyaluronic Acid and Skin Aging
Papakonstantinou E, Roth M, Karakiulakis G
Dermato-Endocrinology, 2012
→
Interconnected hyaluronic acid derivative-based nanoparticles for anticancer drug delivery.
Park JH, Cho HJ, Termsarasab U, Lee JY, Ko SH et al.
Colloids and surfaces. B, Biointerfaces, 2014
→
Hyaluronic Acid Anti-Wrinkle Efficacy
Pavicic T, Gauglitz GG, Lersch P, Schwach-Abdellaoui K, Malle B, Korting HC, Farwick M
Journal of Drugs in Dermatology, 2011
→
The efficacy of hyaluronic acid fragments with amino acid...
Antonio Scarano, E Qorri, A Sbarbati, S A Gehrke, Alessio Frisone, D Amuso + 1 more
Journal of ultrasound, 2024
→
Chitosan, alginate, hyaluronic acid and other novel multi...
Ningning Yuan, Kan Shao, Shan Huang, Cheng Chen
International journal of biological macromolecules, 2023
→
Hydrophobically-modified hyaluronic acid as stabilizer for oil-in-water emulsions to improve epidermis biodistribution of actives.
Zamora P, Movellan J, Grande HJ, Loinaz I, Dupin D
International journal of biological macromolecules, 2025
→
Verified Jun 2026
Data: CosIng · EWG · CIR