The key role of hyaluronic acid m…nment reprogramming.
🔬 Peer-reviewed
The key role of hyaluronic acid molecular weight in HIF-1α pathway-mediated hypoxic microenvironment reprogramming.
Jing Liu, Meishan Piao, Yunxing Li, Cheng Yang, Bingtian Zhao
International journal of biological macromolecules · 2025
Findings
Researchers tested hyaluronic acid at different sizes and found that medium-weight HA (around 30.8 kDa) worked best at reducing damage in low-oxygen environments. This specific size of HA boosted blood vessel growth and skin regeneration in hypoxic tissue — meaning it could help wounds heal better when oxygen is limited.
Design
Review
Sample
n=30
Evidence
Moderate
Journal
International journal of biological macromolecules
Ingredients studied