Liposomes and transferosomes in t…hypertrophic scars.

Researchers found that papain (an enzyme that breaks down excess collagen) can penetrate the skin's outer barrier when delivered via transferosomes—a special nano-delivery system—but doesn't make it through full-thickness skin. When papain was wrapped in transferosomes or liposomes rather than applied as a plain solution, it deposited in the epidermis/dermis without damaging healthy skin cells, whereas papain alone caused noticeable skin degradation.