Liposomes and transferosomes in t…hypertrophic scars.

Researchers found that papain (an enzyme that breaks down collagen) can penetrate the outer skin barrier when delivered via transferosomes—tiny lipid capsules designed to ferry ingredients deeper into skin. However, it stopped at the epidermal/dermal layer and didn't fully penetrate thick skin. The good news: papain caused skin damage when applied as a plain solution, but caused no damage when wrapped in these capsules, suggesting safer delivery is possible.