1,2-Hexanediol

1,2-Hexanediol 1
molecular structure · PubChem CID 94335
AKA: 6920-22-5, DL-1, 2-Dihydroxyhexane, 5, 6-Dihydroxyhexane
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Synthetic
Solvent
Skin Conditioner
Clean
OriginSynthesized from petroleum-derived hydrocarbons or plant-based sugars through chemical reduction processes. Produced via catalytic hydrogenation of hexanedione or fermentation followed by hydrogenation of glucose derivatives.
2-HEXANEDIOL is a cosmetic ingredient used as skin conditioning, solvent. Also known as 1. Rated low hazard by EWG.
Formula
C6H14O2
Mol. Weight
118.17
CAS #
6920-22-5
Form
Liquid
State
Liquid
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Conditions Skin
Dissolves Ingredients
Dissolves other ingredients
The paper trail
🔬Peer-reviewed2 papers →
⚖️Regulatory0 listings
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic (CIR Panel on the ingredient group)
CIR Panel statement covering this group of ingredients; not tested individually (CIR 576)
Not a Sensitizer
6 studies / 6 not sensitizing (CIR 576)
Eye Irritant in Testing
1 study / 1 irritating / reactions severe (CIR 576)
Mixed Skin Irritation Results
3 studies / 1 irritating / 2 not irritating (CIR 576)
Concentration Guide
Leave-on0.2–10%
Rinse-off0.00005–0.8%
0%50%100%
CIR reported use · 2010 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR