1,2,4-Trihydroxybenzene

AKA: 4-BENZENETRIOL, Benzene-1, 4-triol, 533-73-3, Hydroxyhydroquinone, Hydroxyquinol, 4-Hydroxycatechol, IMEXINE OAM
Synthetic
Not Clean
OriginSynthesized from benzene, a basic aromatic hydrocarbon derived from petroleum refining or coal tar sources. Produced through controlled hydroxylation of benzene using oxidation catalysts to add three hydroxyl groups to the benzene ring.
The Expert Panel for Cosmetic Ingredient Safety concluded that 1,2,4-Trihydroxybenzene is safe for use as a hair dye ingredient in the present practices of use and concentration described in this safety assessment.
Formula
C6H6O3
Mol. Weight
126.11
CAS #
533-73-3
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Hair Dyeing
Colors Hair
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Skin Irritant in Testing
2 studies / 2 irritating / reactions slight (CIR 900)
Eye Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 900)
Sensitizer in Testing
2 studies / 2 sensitizing (CIR 900)
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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