2-Oleamido-1,3-Octadecanediol

AKA: 54422-45-6, MEXANYL GZ, 9-Octadecenamide, 3-OCTADECANEDIOL [INCI], (Z)-N-(1, 3-dihydroxyoctadecan-2-yl)octadec-9-enamide
Synthetic
Skin Conditioner
Clean
OriginDerived from oleic acid (an unsaturated fatty acid) and octadecanediol through synthetic chemistry. Produced by amidation reaction between oleic acid derivatives and the diol compound.
2-(9-(Z)-Octadecenylamido)-1,3-octadecanediol
Formula
C36H71NO3
Mol. Weight
566.00
CAS #
54422-45-6
Skin Types
●all-skin-types, gentle
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 674)
Eye Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 674)
Concentration Guide
Leave-on0.01–0.2%
Rinse-off0.01–0.7%
0%50%100%
CIR reported use · report published 2020
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
murphy