4-Amino-2-Hydroxytoluene

AKA: 5-Amino-2-methylphenol, 5-Amino-o-cresol, 2835-95-2, 3-Hydroxy-4-methylaniline, Phenol, 6-Methyl-3-aminophenol, 2-methyl-5-aminophenol, 4-Amino-2-hydroxy-1-methylbenzene
Synthetic
Not Clean
OriginSynthesized from para-cresol (methylphenol) through nitration and subsequent reduction reactions in organic chemistry synthesis. Produced by introducing an amino group and hydroxyl group onto the toluene ring structure via chemical modification.
an ingredient in oxidative hair coloring products; structure in first source
Solubility less than 1 mg/mL at 70 °F (NTP, 1992)
Formula
C7H9NO
Mol. Weight
123.15
CAS #
2835-95-2
Form
Powder
State
3-amino-6-methylphenol is a brown powder. (NTP, 1992)
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
No
Functions
Hair Dyeing
Boosts Collagen
Improves Elasticity
Moisturizing
Colors hair
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
6
CIR
Safe as used
Pregnancy
No
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 141)
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 141)
Mixed Eye Irritation Results
1 study / 1 mixed / reactions mild (CIR 141)
Sensitizer in Testing
4 studies / 4 sensitizing (CIR 141)
Dermal Absorption 0.2%
human in vivo / 3 subjects / 14C-4-Amino-2-Hydroxytoluene in commercial hair dye containing 0.69% mixed with hydrogen peroxide / left on hair 20 min plus 5-8 min working / urine collected about 144 h (CIR 141)
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR