Acetyl Hexapeptide-8 Amide

Acetyl Hexapeptide-8 Amide molecular structure
molecular structure · PubChem
AKA: Acetyl hexapeptide-3, Argireline NP, Hexapeptide 3, Acetyl hexapeptide 3
Synthetic
Skin Conditioner
Not Clean
Acetyl Hexapeptide-8 Amide is the product obtained by the acetylation of Hexapeptide-8 in which the C-terminus is an amide.
Formula
C35H62N14O11S
Mol. Weight
887.0
CAS #
616204-22-9
Form
Powder
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
Reduces fine lines
Traditional Use
Developed in the 1990s as a synthetic peptide designed to mimic the effects of botulinum toxin by relaxing facial muscles, marketed as a topical anti-wrinkle alternative.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Skin Types
●all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR