Acetyl Hexapeptide-8 Amide

Acetyl Hexapeptide-8 Amide molecular structure
molecular structure · PubChem
AKA: Acetyl hexapeptide-3, Argireline NP, Hexapeptide 3, Acetyl hexapeptide 3
Synthetic
Skin Conditioner
Not Clean
OriginSynthesized from hexapeptide-8, a six-amino-acid peptide compound created through chemical synthesis. Produced by acetylation of hexapeptide-8, adding an acetyl group to the peptide's N-terminus while converting the C-terminus to an amide.
Acetyl Hexapeptide-8 Amide is the product obtained by the acetylation of Hexapeptide-8 in which the C-terminus is an amide.
Formula
C35H62N14O11S
Mol. Weight
887.0
CAS #
616204-22-9
Form
Powder
Skin Types
●all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
Reduces fine lines
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 814)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 814)
Mixed Eye Irritation Results
2 studies / 1 irritating / 1 not irritating (CIR 814)
Dermal Absorption 30%
human stratum corneum (from cosmetic surgery donors / ~2 cm2 disks) / in vitro / glass diffusion cell / 0.05% aqueous solution (0.5 ml) / receptor fluid quantified at 2 h (CIR 814)
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR