Acetyl Histidine

AKA: 39145-52-3, N-Acetyl-L-histidine hydrate, L-Histidine, Monohydrate, L-N-acetylhistidine monohydrate, N-ACETYLHISTIDINE MONOHYDRATE, Ac-his-oh.h2o, N-Acetyl-L-histidine Monohydrate
Synthetic
Humectant
Emollient
Skin Conditioner
Not Clean
OriginDerived from the amino acid L-histidine, a naturally occurring compound synthesized for cosmetic use. Produced through acetylation of histidine using acetic anhydride or similar acetylating agents.
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Acetyl Histidine
Formula
C8H13N3O4
Mol. Weight
215.21
CAS #
2407-02-1, 39145-52-3
Form
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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