Acetyl Methionine
molecular structure · PubChem
AKA: N-Acetyl-L-methionine, 65-82-7, N-Acetylmethionine, Acetyl-L-methionine, Methionamine, Thiomedon, Acetylmethionine, L-(N-Acetyl)methionine, L-Methionine
Synthetic
Skin Conditioner
Amino Acid
Clean
N-acetyl-L-methionine is an L-methionine derivative that is L-methionine in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a nutraceutical. It is a N-acetylmethionine, a N-acetyl-L-amino acid and a L-methionine derivative. It is a conjugate acid of a N-acetyl-L-methionine(1-). It is an enantiomer of a N-acetyl-D-methionine.
Effective at 0.5%
Solubility 307000
Formula
C7H13NO3S
Mol. Weight
191.25
CAS #
1115-47-5, 65-82-7
Form
Powder
State
Solid
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A synthetic acetylated amino acid developed for cosmetics to improve absorption and stability. Created as a modified form of the essential amino acid methionine for enhanced skincare delivery.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Concentration Guide
0.0005%
1.0%
0%1%
Reported use
CIR reported use: 0.0005-0.1 | 0.01-1
Regulatory Agencies
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR