Acetyl Proline

AKA: N-Acetyl-L-proline, 68-95-1, 1-Acetyl-L-proline, (2S)-1-acetylpyrrolidine-2-carboxylic acid, L-Proline, (S)-1-acetylpyrrolidine-2-carboxylic acid, (s)-n-acetylproline, (S)-(-)-N-acetylproline
Synthetic
Emollient
Skin Conditioner
Amino Acid
Not Clean
OriginAcetyl proline is synthesized from proline, a naturally occurring amino acid, through acetylation chemistry. The compound is produced by reacting proline with acetic anhydride or acetyl chloride under controlled conditions.
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Acetyl Proline
Solubility >23.6 [ug/mL] (The mean of the results at pH 7.4)
Formula
C7H11NO3
Mol. Weight
157.17
CAS #
68-95-1
Form
Powder
Skin Types
●all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing (CIR 645)
Mixed Skin Irritation Results
2 studies / 1 irritating / 1 mixed / reactions mild (CIR 645)
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2017
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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