murphyAcetyl Tyrosine
AKA: N-Acetyl-L-tyrosine, N-Acetyltyrosine, L-Tyrosine, N-Acetyltyrosine (VAN), L-N-acetyl-Tyrosine, TANOGEN HB
Synthetic
Skin Conditioner
Clean
OriginDerived from the amino acid L-tyrosine, a compound found in protein-rich sources and synthesized chemically. Produced through acetylation of L-tyrosine using acetic anhydride or similar acetylating agents.
N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. [DB00135] is a non-essential amino acid with a polar side group. N-acetyltyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine. It is typically administered as a source of nutritional support where oral nutrition is inadequate or cannot be tolerated.
Solubility 297 mg/mL
Formula
C11H13NO4
Mol. Weight
223.22
CAS #
537-55-3
Form
Powder
State
Solid
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Tanning
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Human test found no phototoxicity in the CIR safety assessment (CIR 645)
Not a Skin Irritant
1 study / 1 not irritating (CIR 645)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 645)
Not an Eye Irritant
2 studies / 2 not irritating (CIR 645)
Dermal Absorption 0.48–30%
4 lab (in vitro) and product formulation studies in the CIR safety assessment (CIR 645)
Concentration Guide
Leave-on0.08–0.3%
Rinse-off0.03%
0%50%100%
CIR reported use · report published 2017
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR