Allantoin Biotin

AKA: UREA, MONO((3AS, 4S, 6AR)-HEXAHYDRO-2-OXO-1H-THIENO(3, 4-D)IMIDAZOLE-4-PENTANOATE), MONO((3AS-(3A.ALPHA., 4.BETA., 6A.ALPHA.))-HEXAHYDRO-2-OXO-1H-THIENO(3, ALLANTOIN BIOTIN [INCI], 1H-THIENO(3, 4-D)IMIDAZOLE-4-PENTANOIC ACID, COMPD. WITH (2, 5-DIOXO-4-IMIDAZOLIDINYL)UREA (1:1)
Synthetic
Soothing
Skin Conditioner
Barrier Support
B Vitamin
Wound Healer
Not Clean
Urea, (2,5-dioxo-4-imidazolydinyl)-, compound with 2H-thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, [3as-(3aalpha,4b,6aalpha)]-
Formula
C14H22N6O6S
Mol. Weight
402.43
CAS #
4492-73-3
Form
Powder
Functions
Anti-Sebum
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Nourishing
Protecting
Traditional Use
A synthetic complex combining allantoin (traditional comfrey derivative used for skin healing) with biotin (vitamin B7, discovered in the 1930s). Developed in modern cosmetics to enhance skin conditioning and strengthen barrier function.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Dermal Absorption 10%
Concentration Guide
Dermal absorption: 10%. Source: CIR Safety Assessment (CIR Seq 310).
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing
🛡️Safety-assessed1 review
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR