Allantoin Glycyrrhetinic Acid

Allantoin Glycyrrhetinic Acid 1
Allantoin Glycyrrhetinic Acid 2
AKA: 4572-09-2, MONO(3.BETA.-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), UREA, MONO((3.BETA., 20.BETA.)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OATE), ALLANTOIN GLYCYRRHETINIC ACID [INCI], MONO(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OATE), OLEAN-12-EN-30-OIC ACID, COMPD. WITH ALLANTOIN
Synthetic
Soothing
Barrier Support
Wound Healer
Acid
Clean
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta., 20.beta.)-, compound with (2,5-dioxo-4-imidazolydinyl)urea (1:1)
Formula
C34H52N4O7
Mol. Weight
628.80
CAS #
4572-09-2
Form
Liquid
State
Solid
Functions
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Soothing
Calms redness, irritation, and inflammation. Your skin's chill pill — great for sensitive, reactive, or post-procedure skin.
Nourishing
Protecting
Traditional Use
Combines allantoin (traditional comfrey derivative for skin healing) with glycyrrhetinic acid (the active compound from licorice root, used for centuries in Ayurvedic and Chinese medicine for inflammation). Developed to maximize soothing and conditioning benefits.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not an Irritant
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Concentration Guide
2%
0%3%
Reg. Limit
FDA OTC limit: 2% (Skin Protectant). Source: FDA OTC Monograph, 21 CFR 347.10. Dermal absorption: 10%. Source: CIR Safety Assessment (CIR Seq 310).
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Skin Types
●all-skin-types, gentle
Best For
Redness
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
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Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR