murphyArachidyl Propionate
AKA: Icosanyl propionate, 65591-14-2, 1-Eicosanol, Propanoate, Eicosanyl propanoate, 1-propanoate, WAXENOL 801, 1-EICOSANYL PROPIONATE
Synthetic
Emollient
Skin Conditioner
Clean
OriginSynthesized from arachidic acid (a saturated fatty acid) and propanol through esterification reactions. Produced by combining arachidic acid with propyl alcohol using catalytic or chemical esterification methods.
The CIR Expert Panel concluded that the alkyl esters, listed subsequently, are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating.
Formula
C23H46O2
Mol. Weight
354.60
CAS #
65591-14-2
Form
Oil
Skin Types
●all-skin-types, gentle
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Product formulation test found no phototoxicity in the CIR safety assessment (CIR 132)
Not Comedogenic
Animal test found no comedogenicity in the CIR safety assessment (CIR 132 and 623)
Not an Eye Irritant
2 studies / 2 not irritating (CIR 132)
Not a Sensitizer
3 studies / 3 not sensitizing (CIR 132)
Mixed Skin Irritation Results
10 studies / 2 mixed / 8 not irritating / reactions minimal to slight (CIR 132 and 623)
Concentration Guide
Leave-on0.002–14.2%
Rinse-off0.0003–14.1%
0%50%100%
CIR reported use · 2012 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR