murphyBenzophenone-4
AKA: Sulisobenzone, 4065-45-6, 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, Sungard, Uval, Benzophenone 4, Seesorb 101S, Syntase 230
Synthetic
Sunscreen Filter
Not Clean
OriginSynthesized from benzophenone, a polycyclic aromatic ketone compound derived from petroleum feedstocks. Produced through sulfonation of benzophenone, introducing sulfonic acid groups to increase water solubility and UV absorption capacity.
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
Solubility 10
Formula
C14H12O6S
Mol. Weight
308.31
CAS #
4065-45-6
Form
Powder
State
Dry Powder
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Caution
Functions
Light Stabilizer
Uv Absorber
Blocks or absorbs UV rays to protect your skin from sun damage, dark spots, and premature aging.
Uv Filter
Blocks or absorbs UV rays to protect your skin from sun damage, dark spots, and premature aging.
Shields from UV damage
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
2 studies / 2 not sensitizing / plus 14 case reports (CIR 219 and 827)
Mixed Eye Irritation Results
3 studies / 2 irritating / 1 mixed / reactions slight to moderate (CIR 827)
Mixed Skin Irritation Results
9 studies / 5 irritating / 3 mixed / 1 not irritating / reactions minimal to corrosive / plus 1 case report (CIR 219 and 827)
Mixed Phototoxicity Results
Both phototoxic and non-phototoxic results in the CIR safety assessment (CIR 219 and 827)
Concentration Guide
Leave-on0.0001–1.6%
Rinse-off0.000035–0.5%
0%50%100%
Reg. limit 10%
CIR reported use · 2020 survey
FDA OTC limit (Sunscreen): 10%. 21 CFR 352.10 | EU/SCCS limit: 5% in rinse-off. Opinion: SCCS/1660/23
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR