Brucine
molecular structure · PubChem
AKA: Brucine sulfate, Brucine sulphate, 4845-99-2, Brucine sulfate anhydrous, Brucine sulphate anhydrous, Strychnidin-10-one, Sulfate (2:1), 10, 11-DIMETHOXYSTRYCHNINE SULFATE
WHAT IS IT?
Synthetic
Not Clean
2,3-Dimethoxystrychnidin-10-one Sulfate (2:1)
Formula
C46H54N4O12S
Mol. Weight
887.00
CAS #
4845-99-2
Form
Liquid
State
Off-white powder; [Sigma-Aldrich MSDS]
WHAT DOES IT DO?
Functions
Denaturant
Makes Alcohol Undrinkable
Reduces Inflammation
Locks In Moisture
Traditional Use
An alkaloid compound extracted from the Strychnos nux-vomica tree, traditionally used in Chinese and Ayurvedic medicine for pain relief and inflammation. Its use in modern cosmetics is minimal and primarily historical.
IS IT CLEAN?
EWG
5
CIR
Safe as used
Pregnancy
No
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA
✔ permitted
EU
✔ permitted
JAPAN
✔ permitted
CANADA
✔ permitted
Regulatory Agencies
EWG
CIR
FDA
EU COSING
Health Canada
IS IT FOR ME?
Skin Types
●
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
No
CAN I TRUST THIS?
The paper trail
🔬
Peer-reviewed
none on file
⚖️
Regulatory
0 listings
🛡️
Safety-assessed
1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR