murphyCapsaicin
AKA: 404-86-4, Zostrix, CAPSAICINE, Qutenza, Trans-Capsaicin, Styptysat, Axsain, Isodecenoic acid vanillylamide, Ausanil
Synthetic
Skin Conditioner
Clean
OriginCapsaicin is derived from vanillylamine and fatty acid chains within the alkaloid compound family. It is synthesized through chemical coupling of vanillylamine with long-chain fatty acids via condensation reactions.
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
Solubility Insoluble in cold water
Formula
C18H27NO3
Mol. Weight
305.40
CAS #
404-86-4
Form
Powder
State
Dark red solid with a volatile pungent odor; [HSDB] Formulated as dry powder, liquid, and liquid spray; [Reference #1] White crystalline solid; [Sigma-Aldrich MSDS]
Skin Types
●all-skin-types, gentle
Best For
Circulation
Pregnancy & Breastfeeding Safe
Caution
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Eye Irritant in Testing
1 study / 1 irritating (CIR 319)
Skin Irritant in Testing
5 studies / 5 irritating (CIR 319)
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2007
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR