murphyCeramide 2
molecular structure · PubChem
AKA: CERAMIDE NG, N-stearoyl dihydrosphingosine, Ceramide NS, Ceramide 2 pure, (2S, 3R)-2-(Octadecanoylamino)octadecane-1
Synthetic
Skin Conditioner
Hair Care
Ceramide
Not Clean
OriginCeramide 2 belongs to the N-acylated sphingolipid chemical family, synthesized from sphingoid base and fatty acid precursors. Produced through esterification or amide coupling of sphinganine with long-chain fatty acids under controlled synthesis conditions.
Ceramide 2 (Retired) is the N-acylated sphingolipid having the erythro structure that conforms generally to the formula, where m has a value ranging from 14 to 28 and n has a value ranging from 10 to 16.The INCI Name, Ceramide 2, originally developed in 1997, was designated with a retired status in 2014. For an interim period of time, trade name assignments formerly published with the INCI Name Ceramide 2 will be retained in the retired monograph, and also published with the new name assignment
Formula
C36H71NO4
Mol. Weight
582.0
CAS #
100403-19-8
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Strengthens skin barrier
Locks in moisture
Prevents moisture loss
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 674)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 674)
Mixed Eye Irritation Results
1 study / 1 mixed / reactions mild (CIR 674)
Concentration Guide
Leave-on0.000005–0.2%
Rinse-off0.0001–0.1%
0%50%100%
CIR reported use · report published 2020
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR