murphyCeramide 5
AKA: Ceramide 5 [INCI], TIC-006, CERAMIDE 5 (RETIRED), CERAMIDE AS (CERAMIDE 5), CERAMIDE 5 (RETIRED) [INCI]
Synthetic
Skin Conditioner
Hair Care
Ceramide
Not Clean
OriginSynthesized from sphingoid bases and fatty acids, belonging to the sphingolipid chemical family. Produced through N-acylation of long-chain amino alcohols with saturated or mono-unsaturated fatty acids.
Ceramide 5 (Retired) is the N-acylated sphingolipid having the erythro structure that conforms generally to the formula, where m has a value ranging from 13 to 27 in which the acyl moiety may be saturated or mono-unsatuarated and n has a value ranging from 10 to 16. Ceramide 5 is similar to Ceramide 4, however, the acylating hydroxy acids are generally longer in Ceramide 5 than in Ceramide 4.The INCI Name, Ceramide 5, originally developed in 1997, was designated with a retired status in 2014. Fo
Formula
C42H83NO4
Mol. Weight
666.1
CAS #
100403-19-8
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Strengthens skin barrier
Locks in moisture
Prevents moisture loss
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 674)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 674)
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2020
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR