Ceramide 6 II

AKA: Ceramide AP, Ceramide VI, Cytomide VI, Biomide 6
Synthetic
Skin Conditioner
Hair Care
Ceramide
Not Clean
OriginDerived from phytosphingosine and long-chain fatty acids, both synthetically produced chemical building blocks. Synthesized through N-acylation of phytosphingosine with variable-length fatty acid chains via esterification.
Ceramide 6 II (Retired) is the N-acylated phytosphingosine having the erythro structure that conforms generally to the formula, where m has a value ranging from 13 to 27 and n has a value ranging from 12 to 20.The INCI Name, Ceramide 6 II, originally developed in 1997, was designated with a retired status in 2014. For an interim period of time, trade name assignments formerly published with the INCI Name Ceramide 6 II will be retained in the retired monograph, and also published with the new nam
Formula
C36H73NO5
Mol. Weight
600.0
CAS #
100403-19-8
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Strengthens skin barrier
Locks in moisture
Prevents moisture loss
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
Leave-on0.00003–0.2%
Rinse-off0.0001–0.00065%
0%50%100%
CIR reported use · report published 2020
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR