Cetrimonium Methosulfate

AKA: Hexadecyltrimethylammonium methyl sulphate, 1-Hexadecanaminium, Methyl sulfate, CRODAZOSOFT DBQ, Ammonium, Hexadecyltrimethyl, Cetyltrimethylammonium methosulfate, CETYLTRIMETHYLAMMONIUM MESYLATE
Synthetic
Preservative
Cleanser
Emulsifier
Skin Conditioner
Hair Care
Not Clean
OriginDerived from fatty alcohols and dimethyl sulfate, both petroleum-derived synthetic compounds. Synthesized through quaternization of fatty alcohols with dimethyl sulfate under controlled chemical conditions.
Hexadecyltrimethylammonium methyl sulphate
Formula
C20H45NO4S
Mol. Weight
395.60
CAS #
65060-02-8
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Fights Bacteria
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 572)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 572)
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR