Cetyl Palmitate

AKA: Palmityl palmitate, 540-10-3, Hexadecyl hexadecanoate, Hexadecanoic acid, Hexadecyl ester, N-Hexadecyl hexadecanoate, PALMITIC ACID, HEXADECYL ESTER, WE(16:0/16:0)
3 Piece Classic Suncare Travel Set
COOLA
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Face Sunscreen Lotion
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Face Sunscreen Lotion - White Tea
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Day & Night Eye Care Duo
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5 Minute Facial
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SOSHE Beauty
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Odacité
Synthetic
Emollient
Skin Conditioner
Fatty Acid
Clean
OriginDerived from palmitic acid and cetyl alcohol, both long-chain fatty acids from plant or petroleum sources. Synthesized through esterification, combining palmitic acid with cetyl alcohol using catalytic conditions.
Palmityl palmitate is a palmitate ester resulting from the formal condensation of palmitic acid with palmityl alcohol. It is used as a thickener and emollient in cosmetics. It has a role as a metabolite. It is functionally related to a hexadecan-1-ol.
Formula
C32H64O2
Mol. Weight
480.80
CAS #
540-10-3
Form
Powder
State
Other Solid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning Emollient
Smooths and softens skin
Softens and smooths skin
Provides scent
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe with qualifications (when formulated to be nonirritating)
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Product formulation test found no phototoxicity in the CIR safety assessment (CIR 238)
Eye Irritant in Testing
1 study / 1 irritating / reactions minimal (CIR 238)
Mixed Skin Irritation Results
7 studies / 3 irritating / 1 mixed / 3 not irritating / reactions minimal to mild (CIR 238)
Mixed Sensitization Results
6 studies / 2 sensitizing / 4 not sensitizing (CIR 238 and 623)
Concentration Guide
Leave-on0.002–11%
Rinse-off0.006–5%
0%50%100%
CIR reported use · 2012 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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