Cetyl Phosphate

AKA: Hexadecyl dihydrogen phosphate, 3539-43-3, Hexadecyl phosphate, 1-Hexadecanol, Dihydrogen phosphate, Hostaphat CC 100, MACKESTER CEP, CRODAFOS MCA
Synthetic
Cleanser
Emulsifier
Clean
OriginDerived from cetyl alcohol and phosphoric acid or phosphate compounds through chemical synthesis. Produced by esterification of cetyl alcohol with phosphoric acid or its salts.
Hexadecyl dihydrogen phosphate
Formula
C16H35O4P
Mol. Weight
322.42
CAS #
3539-43-3
Form
Liquid
State
Liquid
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Surfactant Cleansing
Surfactant Emulsifying
Anti-Inflammatory
Moisturizing
Boosts Collagen
Lifts away dirt and oil
Mixes oil and water
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing (CIR 671)
Skin Irritant in Testing
1 study / 1 irritating (CIR 671)
Concentration Guide
Leave-on0.14–2%
Rinse-off0.5–1%
0%50%100%
CIR reported use · report published 2019
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR