Chlorhexidine Digluconate
molecular structure · PubChem
AKA: Hibiclens, Chlorhexidine gluconate, 18472-51-0, Dyna-hex, Bioscrub, Hibistat, Microderm, Periochip, Periogard
Synthetic
Preservative
Not Clean
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)
Formula
C34H54Cl2N10O14
Mol. Weight
897.80
CAS #
18472-51-0
Form
Liquid
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Oral Care
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Fights Bacteria
Traditional Use
A gluconate salt of chlorhexidine developed to increase water solubility and antimicrobial efficacy. Widely adopted from the 1970s onward in oral rinses, wound care, and antimicrobial skincare formulations.
EWG
4
CIR
Reviewed by CIR
Pregnancy
Caution
CIR Safety Findings
ewg-4
all-shades-safe
Concentration Guide
0.3%
0%0%
Reg. Limit
EU regulatory limit: 0.3%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 42.
Regulatory Agencies
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR