murphyChlorphenesin
AKA: 104-29-0, 3-(4-Chlorophenoxy)-1, 2-propanediol, 3-(4-chlorophenoxy)propane-1, 2-diol, Chlorphenesinum, Chlorphenesine, Clorfenesina, 1, 2-Propanediol, 3-(p-Chlorophenoxy)-1, Glycerol alpha-p-chlorophenyl ether
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Synthetic
Preservative
Not Clean
OriginChlorphenesin is synthesized from a chlorinated phenolic compound within the halogenated organic chemical family. It is produced through chlorination and hydroxylation reactions of phenolic precursors.
1,2-Propanediol, 3-(4-chlorophenoxy)-
Solubility 10000
Formula
C9H11ClO3
Mol. Weight
202.63
CAS #
104-29-0
Form
Liquid
State
Solid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Fights Bacteria
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not Phototoxic
Human test found no phototoxicity in the CIR safety assessment (CIR 612)
Not a Sensitizer
3 studies / 3 not sensitizing / plus 6 case reports (CIR 612)
Eye Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 612)
Mixed Skin Irritation Results
7 studies / 3 irritating / 2 mixed / 2 not irritating / reactions minimal to mild (CIR 612)
Dermal Absorption 57%
16 male Sprague-Dawley CD rats in vivo / 14C-chlorphenesin in 0.05% w/w cold cream mean dose 1.14 mg/kg applied to shaved back 9 cm2 occluded / up to 96 h (CIR 612)
Concentration Guide
Leave-on0.0003–0.3%
Rinse-off0.000008–0.32%
0%50%100%
Reg. limit 0.3%
CIR reported use · 2011 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR