murphyCholine Chloride
AKA: 67-48-1, Lipotril, 2-Hydroxy-N, N-trimethylethanaminium chloride, Hepacholine, Paresan, (2-Hydroxyethyl)trimethylammonium chloride, Hormocline, Biocolina, Biocoline
Synthetic
Humectant
Skin Conditioner
Not Clean
Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.
Solubility Very soluble (NTP, 1992)
Formula
C5H14ClNO
Mol. Weight
139.62
CAS #
67-48-1
Form
Liquid
State
Choline chloride appears as white crystals. Practically neutral aqueous solution. (NTP, 1992)
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 572)
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 572)
Mixed Eye Irritation Results
2 studies / 1 irritating / 1 not irritating (CIR 572)
Dermal Absorption 0.11–3.43%
2 lab (in vitro) studies in the CIR safety assessment (CIR 572)
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2012
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR